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Article

An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants.

Cancer discovery - 1 Nov 2020

Zafra Maria Paz, Parsons Marie J, Kim Jangkyung, Alonso-Curbelo Direna, Goswami Sukanya, Schatoff Emma M, Han Teng, Katti Alyna, Fernandez Maria Teresa Calvo, Wilkinson John E, Piskounova Elena, Dow Lukas E

Abstract excerpt

KRAS is the most frequently mutated oncogene in cancer, yet there is little understanding of how specific KRAS amino acid changes affect tumor initiation, progression, or therapy response. Using high-fidelity CRISPR-based engineering, we created an allelic series of new LSL-Kras mutant mice, reflecting codon 12 and 13 mutations that are highly prevalent in lung (KRASG12C), pancreas (KRASG12R), and colon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32792368
DOI: 10.1158/2159-8290.CD-20-0442
PMCID: PMC7642097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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