Article
A disease model resource reveals core principles of tissue-specific cancer evolution.
Nature - 1 May 2026
Mueller Sebastian, de Andrade Krätzig Niklas, Tschurtschenthaler Markus, Silva Miguel G, Thordsen Chiara, Trozzo Riccardo, Simon Perrine, Saab Frederic, Kaltenbacher Thorsten, Zukowska Magdalena, Lucarelli Daniele, Öllinger Rupert, Griger Joscha, Groß Nina, Groll Tanja, Löprich Jessica, Zaurito Antonio E, Schömig Linus R, Bugter Jeroen M, Bärthel Stefanie, Falcomatà Chiara, Strong Alexander, Brandt Cordelia, Najajreh Mulham, Papargyriou Aristeidis, Maresch Roman, Collins Katharina A N, Sailer David, Schneeweis Christian, Burger Sebastian, Fröhlich Lisa M, Klement Christine, Belka Alexander, Montero Juan J, Jungwirth Ute, Reichert Maximilian, Moser Markus, Neumann Jens, Vassiliou George, Cadiñanos Juan, Varela Ignacio, Marr Carsten, Alonso Daniel F, Lollini Pier-Luigi, Zhao Jean, Chesler Louis, Isacke Clare M, Riedel Angela, Braun Christian J, Sos Martin L, Beleggia Filippo, Reinhardt Hans C, Musteanu Monica, Barbacid Mariano, Quante Michael, Schmidt-Supprian Marc, Schneider Günter, Clare Simon, Lawley Trevor D, Dougan Gordon, Steiger Katja, Conte Nathalie, Bradley Allan, Rad Lena, Saur Dieter, Rad Roland
Abstract excerpt
Oncogenes such as KRAS display marked tissue specificity in their oncogenic potential, genetic interactions and phenotypic effects, but the underlying determinants remain largely unresolved1-5. Here, to address these questions, we developed the Mouse Cancer Cell line Atlas, a broad-utility resource of 590 comprehensively characterized models across a wide range of entities ( www.mcca.tum.de ). Comparative and...
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