Clinical and biological significance of a - 73A > C variation in the CDH1 promoter of patients with sporadic gastric carcinoma.

doi:10.1007/s10120-017-0778-6

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Article

Clinical and biological significance of a - 73A > C variation in the CDH1 promoter of patients with sporadic gastric carcinoma.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Jul 2018

Zhang Baozhen, Zhou Jing, Liu Zhaojun, Gu Liankun, Ji Jiafu, Kim Woo Ho, Deng Dajun

Abstract excerpt

BACKGROUND: CDH1 germline mutations lead to hereditary diffuse gastric carcinomas. However, it is unclear whether genetic variations in the CDH1 promoter affect the progression of sporadic gastric carcinomas (SGCs). METHODS: SGC patients in two independent cohorts with follow-up data were enrolled. The CDH1 genotypes, including the - 73A > C polymorphism (rs28372783), were determined by PCR sequencing. The CDH1...

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PMID: 29168119
DOI: 10.1007/s10120-017-0778-6

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CDH1

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