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Article

CDH1 germline mutations in a Chinese cohort with hereditary diffuse gastric cancer.

Journal of cancer research and clinical oncology - 1 Aug 2022

Pan Zhiwen, Fu Zhixuan, Luo Cong, Bao Yejiang, Wang Mingli, Cao Wenming, Xu Xiaohong

Abstract excerpt

PURPOSE: Germline mutations in CDH1 are associated with hereditary diffuse gastric cancer (HDGC) and have been identified in multiple ethnicities. However, CDH1 germline mutations have seldom been documented in Chinese patients with HDGC, and their frequency remains unclear. Here, we aimed to examine the frequency of CDH1 germline mutations in Chinese patients with HDGC. In total, 285 patients who met the...

Topics

Cadherins
China
Female
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Male
Pedigree
Stomach Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34537906
DOI: 10.1007/s00432-021-03775-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-34537906-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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