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Article

Identification and characterization of CDH1 germline variants in sporadic gastric cancer patients and in individuals at risk of gastric cancer.

PloS one - 1 Jan 2013

Garziera Marica, Canzonieri Vincenzo, Cannizzaro Renato, Geremia Silvano, Caggiari Laura, De Zorzi Mariangela, Maiero Stefania, Orzes Enrico, Perin Tiziana, Zanussi Stefania, De Paoli Paolo, De Re Valli

Abstract excerpt

OBJECTIVE: To screen and characterize germline variants for E-cadherin (CDH1) in non-hereditary gastric cancer (GC) patients and in subjects at risk of GC. METHODS: 59 GCs, 59 first degree relatives (FDRs) of GC, 20 autoimmune metaplastic atrophic gastritis (AMAGs) and 52 blood donors (BDs) were analyzed for CDH1 by direct sequencing, structural modelling and bioinformatics. Functional impact on splicing was...

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Identifiers

PMID: 24204729
DOI: 10.1371/journal.pone.0077035
PMCID: PMC3812172

Genes

CDH1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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