Article
Identification and characterization of CDH1 germline variants in sporadic gastric cancer patients and in individuals at risk of gastric cancer.
PloS one - 1 Jan 2013
Garziera Marica, Canzonieri Vincenzo, Cannizzaro Renato, Geremia Silvano, Caggiari Laura, De Zorzi Mariangela, Maiero Stefania, Orzes Enrico, Perin Tiziana, Zanussi Stefania, De Paoli Paolo, De Re Valli
Abstract excerpt
OBJECTIVE: To screen and characterize germline variants for E-cadherin (CDH1) in non-hereditary gastric cancer (GC) patients and in subjects at risk of GC. METHODS: 59 GCs, 59 first degree relatives (FDRs) of GC, 20 autoimmune metaplastic atrophic gastritis (AMAGs) and 52 blood donors (BDs) were...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alternative Splicing
- Antigens, CD
- Base Sequence
- Cadherins
- Cell Line
- DNA Mutational Analysis
- Female
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Immunohistochemistry