Article

Hereditary Diffuse Gastric Cancer in a Japanese Family with CDH1 Mutation: Three Individuals Undergoing Total Gastrectomy Following Presymptomatic Genomic Diagnosis

2022-11-09

Abstract excerpt

<h4>Background: </h4> ; Germline pathogenic variants in the E-cadherin gene CDH1 cause hereditary diffuse gastric cancer (HDGC), which is an autosomal dominant cancer syndrome, accounting for 1% of all gastric cancers. HDGC harboring a CDH 1 variant is extremely rare in Japan. Method; Here, we describe four cases of HDGC in a single Japanese family. Results; The proband exhibited advanced and metastatic gastric...

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Literature Corpus work: ee14ac65-380c-5a57-b063-7ef1569a023b
DOI: 10.21203/rs.3.rs-2232044/v1

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