Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population.

BMC cancer - 15 May 2008

Nasri Soroush, More Helen, Graziano Francesco, Ruzzo Annamaria, Wilson Emily, Dunbier Anita, McKinney Cushla, Merriman Tony, Guilford Parry, Magnani Mauro, Humar Bostjan

Abstract excerpt

BACKGROUND: Inherited genetic factors such as E-cadherin (CDH1) promoter variants are believed to influence the risk towards sporadic diffuse gastric cancer (DGC). Recently, a new regulatory region essential for CDH1 transcription has been identified in CDH1 intron 2. METHODS: We genotyped all known polymorphisms located within conserved sequences of CDH1 intron 2 (rs10673765, rs9932686, rs1125557, rs9282650,...

Topics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Adult
Aged
Cadherins
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Humans
Introns
Italy
Male
Middle Aged
Polymorphism, Genetic
Regulatory Elements, Transcriptional
Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 18482459
DOI: 10.1186/1471-2407-8-138
PMCID: PMC2412889

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18482459-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population.PMID 18482459Read ↗

Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer.Semantic proximity Read ↗

Hereditary diffuse gastric cancer and E-cadherin: description of the first germline mutation in an Italian family.Semantic proximity Read ↗

Low expression of E-Cadherin and CDH1 variants associated with diffuse gastric cancer.Semantic proximity Read ↗

The G/A nucleotide change at cDNA position 2494 in the E-cadherin gene (CDH1): analysis in Italian patients.Semantic proximity Read ↗

CDH1 polymorphisms and haplotypes in sporadic diffuse and intestinal gastric cancer: a case-control study based on direct sequencing analysis.Semantic proximity Read ↗

E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer.Semantic proximity Read ↗

Screening E-cadherin germline mutations in Italian patients with familial diffuse gastric cancer: an analysis in the District of Urbino, Region Marche, Central Italy.Semantic proximity Read ↗

Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene.Semantic proximity Read ↗

Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families.Semantic proximity Read ↗

The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice.Semantic proximity Read ↗

Hereditary Diffuse Gastric Cancer Syndrome: CDH1 Mutations and Beyond.Semantic proximity Read ↗

Overview on new progress of hereditary diffuse gastric cancer with CDH1 variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.