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Article

CDH1 germline variants are enriched in patients with colorectal cancer, gastric cancer, and breast cancer.

British journal of cancer - 1 Mar 2022

Adib Elio, El Zarif Talal, Nassar Amin H, Akl Elie W, Abou Alaiwi Sarah, Mouhieddine Tarek H, Esplin Edward D, Hatchell Kathryn, Nielsen Sarah M, Rana Huma Q, Choueiri Toni K, Kwiatkowski David J, Sonpavde Guru

Abstract excerpt

BACKGROUND AND AIMS: CDH1 germline variants have been linked to heritability in diffuse gastric (DGC) and lobular breast cancer (LBC). Studies have not yet assessed whether CDH1 is a cancer-susceptibility gene in other cancers. Herein, we mapped the landscape of pathogenic and likely pathogenic (P/LP) germline variants in CDH1 across various cancers and ethnicities. METHODS: We evaluated CDH1 germline P/LP...

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Identifiers

PMID: 34949788
DOI: 10.1038/s41416-021-01673-7
PMCID: PMC8888603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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