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Article

DNA/RNA hybrid substrates modulate the catalytic activity of purified AID.

Molecular immunology - 1 Jan 2018

Abdouni Hala S, King Justin J, Ghorbani Atefeh, Fifield Heather, Berghuis Lesley, Larijani Mani

Abstract excerpt

Activation-induced cytidine deaminase (AID) converts cytidine to uridine at Immunoglobulin (Ig) loci, initiating somatic hypermutation and class switching of antibodies. In vitro, AID acts on single stranded DNA (ssDNA), but neither double-stranded DNA (dsDNA) oligonucleotides nor RNA, and it is believed that transcription is the in vivo generator of ssDNA targeted by AID. It is also known that the Ig loci,...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Source

Identifiers

PMID: 29161581
DOI: 10.1016/j.molimm.2017.11.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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