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Article

Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase

13 Aug 2013

Abstract excerpt

Activation-induced deaminase (AID), a member of the larger AID/APOBEC family, is the key catalyst in initiating antibody somatic hypermutation and class-switch recombination. The DNA deamination model accounting for AID's functional role posits that AID deaminates genomic deoxycytosine bases within the immunoglobulin locus, activating downstream repair pathways that result in antibody maturation. Although this...

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PMID: 23942124
DOI: 10.1073/pnas.1306345110

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