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Article

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations.

Nucleic acids research - 15 Jun 2003

Sohail Anjum, Klapacz Joanna, Samaranayake Mala, Ullah Asad, Bhagwat Ashok S

Abstract excerpt

Activation-induced cytidine deaminase (AID) is required for the maturation of antibodies in higher vertebrates, where it promotes somatic hypermutation (SHM), class switch recombination and gene conversion. While it is known that SHM requires high levels of transcription of the target genes, it is unclear whether this is because AID targets transcribed genes. We show here that the human AID promotes C to T...

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Identifiers

PMID: 12799424
DOI: 10.1093/nar/gkg464
PMCID: PMC162340

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations.PMID 12799424Read ↗

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