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Article

Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification.

DNA repair - 1 Jul 2016

Pham Phuong, Afif Samir A, Shimoda Mayuko, Maeda Kazuhiko, Sakaguchi Nobuo, Pedersen Lars C, Goodman Myron F

Abstract excerpt

Activation-induced deoxycytidine deaminase (AID) initiates somatic hypermutation (SHM) and class-switch recombination (CSR) by deaminating C→U during transcription of Ig-variable (V) and Ig-switch (S) region DNA, which is essential to produce high-affinity antibodies. Here we report the crystal structure of a soluble human AID variant at 2.8Å resolution that favors targeting WRC motifs (W=A/T, R=A/G) in vitro,...

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Identifiers

PMID: 27258794
DOI: 10.1016/j.dnarep.2016.05.029
PMCID: PMC4917410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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