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Article

Determinants of sequence-specificity within human AID and APOBEC3G.

DNA repair - 4 May 2010

Carpenter Michael A, Rajagurubandara Erandi, Wijesinghe Priyanga, Bhagwat Ashok S

Abstract excerpt

Human APOBEC3G (A3G) and activation-induced deaminase (AID) belong to a family of DNA-cytosine deaminases. While A3G targets the last C in a run of C's, AID targets C in the consensus sequence WRC (W is A or T and R is a purine). Guided by the structures of the A3G carboxyl-terminal catalytic domain (A3G-CTD), we identified two potential regions (region 1 and region 2) that may interact with DNA and swapped the...

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Source

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Identifiers

PMID: 20338830
DOI: 10.1016/j.dnarep.2010.02.010
PMCID: PMC2878719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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