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Article

Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitro.

Scientific reports - 20 Jun 2017

Budzko Lucyna, Jackowiak Paulina, Kamel Karol, Sarzynska Joanna, Bujnicki Janusz M, Figlerowicz Marek

Abstract excerpt

Activation-induced cytidine deaminase (AID) is known for its established role in antibody production. AID induces the diversification of antibodies by deaminating deoxycytidine (C) within immunoglobulin genes. The capacity of AID to deaminate 5-methyldeoxycytidine (5 mC) and/or 5-hydroxymethyldeoxycytidine (5 hmC), and consequently AID involvement in active DNA demethylation, is not fully resolved. For instance,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28634398
DOI: 10.1038/s41598-017-03936-x
PMCID: PMC5478644

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