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Article

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

1 Oct 2000

Abstract excerpt

A genome scan for B10-derived loci that reduce the frequency of diabetes and insulitis in NOD mice demonstrated a large region (34 cM) of linkage on the proximal end of chromosome 1. This locus was designated Idd5 and encompassed candidate genes including Il1r1, Il1r2, Stat1, Stat4, Nramp1, and Bcl2. In the current study, we have confirmed the existence of Idd5 by developing a series of congenic mouse strains...

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Identifiers

PMID: 11016460
DOI: 10.2337/diabetes.49.10.1744

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Related research

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NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.PMID 11016460Read ↗

Further mapping of the Idd5.1 locus for autoimmune diabetes in NOD mice.Semantic proximity Read ↗

The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137.Semantic proximity Read ↗

Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci.Semantic proximity Read ↗

Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes.Semantic proximity Read ↗

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes.Semantic proximity Read ↗

Two genetic loci regulate T cell-dependent islet inflammation and drive autoimmune diabetes pathogenesis.Semantic proximity Read ↗

Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice.Semantic proximity Read ↗

Mapping by genetic interaction: high-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse.Semantic proximity Read ↗

The idd4 locus displays sex-specific epistatic effects on type 1 diabetes susceptibility in nonobese diabetic mice.Semantic proximity Read ↗

Localization of Idd11 using NOD congenic mouse strains: elimination of Slc9a1 as a candidate gene.Semantic proximity Read ↗

Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis.Semantic proximity Read ↗

Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes.Semantic proximity Read ↗

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