Article
Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice.
International immunology - 1 May 2009
Jiang Fang, Yoshida Taku, Nakaki Fumio, Terawaki Seigo, Chikuma Shunsuke, Kato Yu, Okazaki Il-Mi, Honjo Tasuku, Okazaki Taku
Abstract excerpt
The non-obese diabetic (NOD) mouse strain is prone to developing various autoimmune syndromes including type I diabetes mellitus (T1DM), sialadenitis, thyroiditis and pancreatitis. Although the genetic basis of T1DM has been extensively analyzed, genetic factors that modify the other autoimmune phenotypes are largely unknown. We have recently reported that NOD mice with anti-diabetogenic MHC haplotype (H-2(b))...
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