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Article

SPARCL1 Accelerates Symptom Onset in Alzheimer's Disease and Influences Brain Structure and Function During Aging.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Seddighi Sahba, Varma Vijay R, An Yang, Varma Sudhir, Beason-Held Lori L, Tanaka Toshiko, Kitner-Triolo Melissa H, Kraut Michael A, Davatzikos Christos, Thambisetty Madhav

Abstract excerpt

We recently reported that alpha-2 macroglobulin (A2M) is a biomarker of neuronal injury in Alzheimer's disease (AD) and identified a network of nine genes co-expressed with A2M in the brain. This network includes the gene encoding SPARCL1, a protein implicated in synaptic maintenance. Here, we examine whether SPARCL1 is associated with longitudinal changes in brain structure and function in older individuals at...

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Identifiers

PMID: 29154276
DOI: 10.3233/JAD-170557
PMCID: PMC5934753

Genes

SPARCL1

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