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Longitudinal APOE4- and amyloid-dependent changes in the blood transcriptome in cognitively intact older adults

12 Jul 2023

Abstract excerpt

Abstract Background Gene expression is dysregulated in Alzheimer’s disease (AD) patients, both in peripheral blood and post mortem brain. We investigated peripheral whole-blood gene (co)expression to determine molecular changes prior to symptom onset. Methods RNA was extracted and sequenced for 65 cognitively healthy F-PACK participants (65 (56–80) years, 34 APOE4 non-carriers, 31 APOE4 carriers), at baseline and...

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PMID: 37438770
DOI: 10.1186/s13195-023-01242-5

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