Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Risk factors underlying brain structure change rate in cognitive decline: Results from genomewide and phenomewide investigations.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2026

Jin Yin, Topaloudi Apostolia, Drineas Petros, Paschou Peristera

Abstract excerpt

INTRODUCTION: The genetic and clinical factors influencing the rate of brain structure change in cognitive decline remain poorly understood. This study aimed to identify genetic variants and risk factors contributing to these changes and explore potential causal relationships. METHODS: We analyzed data from 2036 individuals across three longitudinal cohorts to assess change rates in 17 brain regions associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Atrophy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognitive Dysfunction

Share to Diabetes Mellitus, Type 2

Share to Longitudinal Studies

Share to Magnetic Resonance Imaging

Share to Mendelian Randomization Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 42010774
DOI: 10.1002/alz.71411
PMCID: PMC13095869

Genes

APOC1
BEAN1
SDHC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Risk factors underlying brain structure change rate in cognitive decline: Results from genomewide and phenomewide investigations.PMID 42010774Read ↗

A genome-wide scan for common variants affecting the rate of age-related cognitive decline.Semantic proximity Read ↗

Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespanSemantic proximity Read ↗

Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study.Semantic proximity Read ↗

SPARCL1 Accelerates Symptom Onset in Alzheimer's Disease and Influences Brain Structure and Function During Aging.Semantic proximity Read ↗

A blood biomarker of the pace of aging is associated with brain structure: replication across three cohortsSemantic proximity Read ↗

Brain change trajectories in healthy adults correlate with Alzheimer's related genetic variation and memory decline across life.Semantic proximity Read ↗

Genome-wide analysis of subcortical aging identifies a spatially structured pattern of genetic associationsSemantic proximity Read ↗

Accelerated brain change in healthy adults is associated with genetic risk for Alzheimer’s disease and uncovers adult lifespan memory declineSemantic proximity Read ↗

Using deep learning to predict brain age from brain magnetic resonance images and cognitive tests reveals that anatomical and functional brain aging are phenotypically and genetically distinctSemantic proximity Read ↗

Vulnerability to memory decline in aging – a mega-analysis of structural brain changeSemantic proximity Read ↗

Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging.Semantic proximity Read ↗

An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortalitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.