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Article

Genetic variants beyond amyloid and tau associated with cognitive decline: A cohort study.

Neurology - 27 Oct 2020

Kim Hang-Rai, Lee Taeyeop, Choi Jung Kyoon, Jeong Yong

Abstract excerpt

OBJECTIVE: To identify single nucleotide polymorphisms (SNPs) associated with cognitive decline independent of β-amyloid (Aβ) and tau pathology in Alzheimer disease (AD). METHODS: Discovery and replication datasets consisting of 414 individuals (94 cognitively normal control [CN], 185 with mild cognitive impairment [MCI], and 135 with AD) and 72 individuals (22 CN, 39 with MCI, and 11 with AD), respectively, were...

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Identifiers

PMID: 32938779
DOI: 10.1212/WNL.0000000000010724
PMCID: PMC8105895

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