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Article

Deep neural networks and genome-wide associations reveal the polygenic architecture of local brain aging.

GeroScience - 1 Jun 2026

Kim Nicholas J, Mishra Ayati, Chowdhury Nahian F, Anderson Samuel D, Vega Owen M, Chaudhari Nikhil N, Buetow Kenneth H, Thompson Paul M, Irimia Andrei

Abstract excerpt

Local brain age (LBA) is a regional metric of brain aging that offers a spatially resolved alternative to global brain age, but whose genetic basis is unexplored. This study reports the first genome-wide association study of cortical LBA, as estimated by a deep neural network from the T1-weighted magnetic resonance images of 41,708 cognitively normal adults in the UK Biobank. We identified 1,212 single-nucleotide...

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Identifiers

PMID: 41381974
DOI: 10.1007/s11357-025-02046-1
PMCID: PMC13356123

Genes

GMNC
KCNK2
MSL2
NUAK1

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