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Genome-wide analysis of subcortical aging identifies a spatially structured pattern of genetic associations

1 Aug 2026

Abstract excerpt

Local brain age (LBA) is a spatially resolved biomarker of brain aging that captures regional deviations from chronological age, yet its genetic architecture in the subcortex remains unexplored. Here, we present the first genome-wide association study (GWAS) of subcortical LBA, estimated using a deep neural network applied to T1-weighted MRI scans from 41,957 cognitively normal participants in the UK Biobank. We...

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PMID: 42541656
DOI: 10.1007/s11357-026-02453-y

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