Article
Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish.
Nature communications - 7 Nov 2017
Cheng Xiao-Ning, Shao Ming, Li Ji-Tong, Wang Yan-Fei, Qi Jing, Xu Zhi-Gang, Shi De-Li
Abstract excerpt
Gastrulation is a fundamental morphogenetic event that requires polarised cell behaviours for coordinated asymmetric cell movements. Wnt/PCP signalling plays a critical role in this process. Dishevelled is an important conserved scaffold protein that relays Wnt/PCP signals from membrane receptors to the modulation of cytoskeleton organisation. However, it remains unclear how its activity is regulated for the...
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