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Article

Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry.

Nature communications - 2 Aug 2024

Kurup Akshai Janardhana, Bailet Florian, Fürthauer Maximilian

Abstract excerpt

Myosin1D (Myo1D) has recently emerged as a conserved regulator of animal Left-Right (LR) asymmetry that governs the morphogenesis of the vertebrate central LR Organizer (LRO). In addition to Myo1D, the zebrafish genome encodes the closely related Myo1G. Here we show that while Myo1G also controls LR asymmetry, it does so through an entirely different mechanism. Myo1G promotes the Nodal-mediated transfer of...

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Identifiers

PMID: 39095343
DOI: 10.1038/s41467-024-50868-y
PMCID: PMC11297164

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