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Article

Gpr125 modulates Dishevelled distribution and planar cell polarity signaling.

Development (Cambridge, England) - 1 Jul 2013

Li Xin, Roszko Isabelle, Sepich Diane S, Ni Mingwei, Hamm Heidi E, Marlow Florence L, Solnica-Krezel Lilianna

Abstract excerpt

During vertebrate gastrulation, Wnt/planar cell polarity (PCP) signaling orchestrates polarized cell behaviors underlying convergence and extension (C&E) movements to narrow embryonic tissues mediolaterally and lengthen them anteroposteriorly. Here, we have identified Gpr125, an adhesion G protein-coupled receptor, as a novel modulator of the Wnt/PCP signaling system. Excess Gpr125 impaired C&E movements and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23821037
DOI: 10.1242/dev.094839
PMCID: PMC3699285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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