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Article

Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding.

Nature cell biology - 1 Jul 2005

Jenny Andreas, Reynolds-Kenneally Jessica, Das Gishnu, Burnett Micheal, Mlodzik Marek

Abstract excerpt

Epithelial planar cell polarity (PCP) is evident in the cellular organization of many tissues in vertebrates and invertebrates. In mammals, PCP signalling governs convergent extension during gastrulation and the organization of a wide variety of structures, including the orientation of body hair and sensory hair cells of the inner ear. In Drosophila melanogaster, PCP is manifest in adult tissues, including...

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Identifiers

PMID: 15937478
DOI: 10.1038/ncb1271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding.PMID 15937478Read ↗

Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling.Semantic proximity Read ↗

Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes.Semantic proximity Read ↗

Novel regulators of planar cell polarity: a genetic analysis in Drosophila.Semantic proximity Read ↗

Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear.Semantic proximity Read ↗

PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates.Semantic proximity Read ↗

Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish.Semantic proximity Read ↗

The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors.Semantic proximity Read ↗

Structure-function dissection of the frizzled receptor in Drosophila melanogaster suggests different mechanisms of action in planar polarity and canonical Wnt signaling.Semantic proximity Read ↗

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Planar Cell Polarity Effector Fritz Interacts with Dishevelled and Has Multiple Functions in Regulating PCP.Semantic proximity Read ↗

The Wnt co-receptor Arrow-LRP5/6 is required for Planar Cell Polarity establishment in <i>Drosophila</i>Semantic proximity Read ↗

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