Article
Mutational analysis of dishevelled genes in zebrafish reveals distinct functions in embryonic patterning and gastrulation cell movements.
PLoS genetics - 1 Aug 2018
Xing Yan-Yi, Cheng Xiao-Ning, Li Yu-Long, Zhang Chong, Saquet Audrey, Liu Yuan-Yuan, Shao Ming, Shi De-Li
Abstract excerpt
Wnt signaling plays critical roles in dorsoventral fate specification and anteroposterior patterning, as well as in morphogenetic cell movements. Dishevelled proteins, or Dvls, mediate the activation of Wnt/ß-catenin and Wnt/planar cell polarity pathways. There are at least three highly conserved Dvl proteins in vertebrates, but the implication of each Dvl in key early developmental processes remains poorly...
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