Article
Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner.
Nature communications - 12 Jun 2018
Lee Yoonmi, Kim Nam Hee, Cho Eunae Sandra, Yang Ji Hye, Cha Yong Hoon, Kang Hee Eun, Yun Jun Seop, Cho Sue Bean, Lee Seon-Hyeong, Paclikova Petra, Radaszkiewicz Tomasz W, Bryja Vitezslav, Kang Chi Gu, Yuk Young Soo, Cha So Young, Kim Soo-Youl, Kim Hyun Sil, Yook Jong In
Abstract excerpt
Phosphorylation-dependent YAP translocation is a well-known intracellular mechanism of the Hippo pathway; however, the molecular effectors governing YAP cytoplasmic translocation remains undefined. Recent findings indicate that oncogenic YAP paradoxically suppresses Wnt activity. Here, we show that Wnt scaffolding protein Dishevelled (DVL) is responsible for cytosolic translocation of phosphorylated YAP....
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