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Article

Dishevelled controls cell polarity during Xenopus gastrulation.

Nature - 4 May 2000

Wallingford J B, Rowning B A, Vogeli K M, Rothbächer U, Fraser S E, Harland R M

Abstract excerpt

Although cell movements are vital for establishing the normal architecture of embryos, it is unclear how these movements are regulated during development in vertebrates. Inhibition of Xenopus Dishevelled (Xdsh) function disrupts convergent extension movements of cells during gastrulation, but the mechanism of this effect is unclear, as cell fates are not affected. In Drosophila, Dishevelled controls both cell...

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PMID: 10811222
DOI: 10.1038/35011077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Dishevelled controls cell polarity during Xenopus gastrulation.PMID 10811222Read ↗

dishevelled is required during wingless signaling to establish both cell polarity and cell identity.Semantic proximity Read ↗

Neural tube closure requires Dishevelled-dependent convergent extension of the midline.Semantic proximity Read ↗

Xenopus Dishevelled signaling regulates both neural and mesodermal convergent extension: parallel forces elongating the body axis.Semantic proximity Read ↗

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Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling.Semantic proximity Read ↗

The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.Semantic proximity Read ↗

Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation.Semantic proximity Read ↗

The planar polarity gene strabismus regulates convergent extension movements in Xenopus.Semantic proximity Read ↗

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