Article
Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1.
PloS one - 1 Jan 2009
Louie Sarah H, Yang Xiao Yong, Conrad William H, Muster Jeanot, Angers Stephane, Moon Randall T, Cheyette Benjamin N R
Abstract excerpt
BACKGROUND: Wnts are evolutionarily conserved ligands that signal through beta-catenin-dependent and beta-catenin-independent pathways to regulate cell fate, proliferation, polarity, and movements during vertebrate development. Dishevelled (Dsh/Dvl) is a multi-domain scaffold protein required for virtually all known Wnt signaling activities, raising interest in the identification and functions of Dsh-associated...
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