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Article

Accurate detection of chemical modifications in RNA by mutational profiling (MaP) with ShapeMapper 2.

RNA (New York, N.Y.) - 1 Feb 2018

Busan Steven, Weeks Kevin M

Abstract excerpt

Mutational profiling (MaP) enables detection of sites of chemical modification in RNA as sequence changes during reverse transcription (RT), subsequently read out by massively parallel sequencing. We introduce ShapeMapper 2, which integrates careful handling of all classes of adduct-induced sequence changes, sequence variant correction, basecall quality filters, and quality-control warnings to now identify RNA...

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Identifiers

PMID: 29114018
DOI: 10.1261/rna.061945.117
PMCID: PMC5769742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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