Article
RNA structure through multidimensional chemical mapping.
Quarterly reviews of biophysics - 1 Jan 2016
Tian Siqi, Das Rhiju
Abstract excerpt
The discoveries of myriad non-coding RNA molecules, each transiting through multiple flexible states in cells or virions, present major challenges for structure determination. Advances in high-throughput chemical mapping give new routes for characterizing entire transcriptomes in vivo, but the resulting one-dimensional data generally remain too information-poor to allow accurate de novo structure determination....
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