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Article

Accurate RNA consensus sequencing for high-fidelity detection of transcriptional mutagenesis-induced epimutations.

Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 2017

Reid-Bayliss Kate S, Loeb Lawrence A

Abstract excerpt

Transcriptional mutagenesis (TM) due to misincorporation during RNA transcription can result in mutant RNAs, or epimutations, that generate proteins with altered properties. TM has long been hypothesized to play a role in aging, cancer, and viral and bacterial evolution. However, inadequate methodologies have limited progress in elucidating a causal association. We present a high-throughput, highly accurate RNA...

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PMID: 28798064
DOI: 10.1073/pnas.1709166114
PMCID: PMC5584456

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