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Mutation signature filtering enables high-fidelity RNA structure probing at all four nucleobases with DMS.

Nucleic acids research - 8 Sept 2023

Mitchell David, Cotter Jennifer, Saleem Irfana, Mustoe Anthony M

Abstract excerpt

Chemical probing experiments have transformed RNA structure analysis, enabling high-throughput measurement of base-pairing in living cells. Dimethyl sulfate (DMS) is one of the most widely used structure probing reagents and has played a pivotal role in enabling next-generation single-molecule probing analyses. However, DMS has traditionally only been able to probe adenine and cytosine nucleobases. We previously...

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PMID: 37334863
DOI: 10.1093/nar/gkad522
PMCID: PMC10484685

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