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Article

Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1.

PLoS pathogens - 1 Nov 2017

Mackelprang Romel D, Bamshad Michael J, Chong Jessica X, Hou Xuanlin, Buckingham Kati J, Shively Kathryn, deBruyn Guy, Mugo Nelly R, Mullins James I, McElrath M Juliana, Baeten Jared M, Celum Connie, Emond Mary J, Lingappa Jairam R

Abstract excerpt

Host genetic variation modifying HIV-1 acquisition risk can inform development of HIV-1 prevention strategies. However, associations between rare or intermediate-frequency variants and HIV-1 acquisition are not well studied. We tested for the association between variation in genic regions and extreme HIV-1 acquisition phenotypes in 100 sub-Saharan Africans with whole genome sequencing data. Missense variants in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29108000
DOI: 10.1371/journal.ppat.1006703
PMCID: PMC5690691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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