Article
Multicohort genomewide association study reveals a new signal of protection against HIV-1 acquisition.
The Journal of infectious diseases - 1 Apr 2012
Limou Sophie, Delaneau Olivier, van Manen Daniëlle, An Ping, Sezgin Efe, Le Clerc Sigrid, Coulonges Cédric, Troyer Jennifer L, Veldink Jan H, van den Berg Leonard H, Spadoni Jean-Louis, Taing Lieng, Labib Taoufik, Montes Matthieu, Delfraissy Jean-François, Schachter François, O'Brien Stephen J, Buchbinder Susan, van Natta Mark L, Jabs Douglas A, Froguel Philippe, Schuitemaker Hanneke, Winkler Cheryl A, Zagury Jean-François
Abstract excerpt
BACKGROUND: To date, only mutations in CCR5 have been shown to confer resistance to human immunodeficiency virus type 1 (HIV-1) infection, and these explain only a small fraction of the observed variability in HIV susceptibility. METHODS: We performed a meta-analysis between 2 independent European genomewide association studies, each comparing HIV-1 seropositive cases with normal population controls known to be...
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