Article
Associations of common variants in the BST2 region with HIV-1 acquisition in African American and European American people who inject drugs.
AIDS (London, England) - 24 Apr 2015
Hancock Dana B, Gaddis Nathan C, Levy Joshua L, Bierut Laura J, Kral Alex H, Johnson Eric O
Abstract excerpt
OBJECTIVE: The bone marrow stromal cell antigen 2 (BST2) gene encodes a host restriction factor that acts as an innate immune sensor of HIV-1 exposure and suppresses release of HIV-1 particles. We aimed to identify associations of variants in the BST2 gene region with HIV-1 acquisition and disease progression. DESIGN/METHODS: Using HIV+ cases and HIV- controls from the Urban Health Study (n=3136 African Americans...
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