Article
Novel genetic locus implicated for HIV-1 acquisition with putative regulatory links to HIV replication and infectivity: a genome-wide association study.
PloS one - 1 Jan 2015
Johnson Eric O, Hancock Dana B, Gaddis Nathan C, Levy Joshua L, Page Grier, Novak Scott P, Glasheen Cristie, Saccone Nancy L, Rice John P, Moreau Michael P, Doheny Kimberly F, Romm Jane M, Brooks Andrew I, Aouizerat Bradley E, Bierut Laura J, Kral Alex H
Abstract excerpt
Fifty percent of variability in HIV-1 susceptibility is attributable to host genetics. Thus identifying genetic associations is essential to understanding pathogenesis of HIV-1 and important for targeting drug development. To date, however, CCR5 remains the only gene conclusively associated with HIV acquisition. To identify novel host genetic determinants of HIV-1 acquisition, we conducted a genome-wide...
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