Article
Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls.
PLoS pathogens - 1 Jan 2013
McLaren Paul J, Coulonges Cédric, Ripke Stephan, van den Berg Leonard, Buchbinder Susan, Carrington Mary, Cossarizza Andrea, Dalmau Judith, Deeks Steven G, Delaneau Olivier, De Luca Andrea, Goedert James J, Haas David, Herbeck Joshua T, Kathiresan Sekar, Kirk Gregory D, Lambotte Olivier, Luo Ma, Mallal Simon, van Manen Daniëlle, Martinez-Picado Javier, Meyer Laurence, Miro José M, Mullins James I, Obel Niels, O'Brien Stephen J, Pereyra Florencia, Plummer Francis A, Poli Guido, Qi Ying, Rucart Pierre, Sandhu Manj S, Shea Patrick R, Schuitemaker Hanneke, Theodorou Ioannis, Vannberg Fredrik, Veldink Jan, Walker Bruce D, Weintrob Amy, Winkler Cheryl A, Wolinsky Steven, Telenti Amalio, Goldstein David B, de Bakker Paul I W, Zagury Jean-François, Fellay Jacques
Abstract excerpt
Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have been interrogated using GWAS, although in generally small samples. Under the auspices of the International Collaboration for the Genomics of HIV, we have...
Topics
- Case-Control Studies
- Cohort Studies
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- HIV Infections