Article
Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study.
PloS one - 1 Jan 2008
Dalmasso Cyril, Carpentier Wassila, Meyer Laurence, Rouzioux Christine, Goujard Cécile, Chaix Marie-Laure, Lambotte Olivier, Avettand-Fenoel Véronique, Le Clerc Sigrid, de Senneville Laure Denis, Deveau Christiane, Boufassa Faroudy, Debré Patrice, Delfraissy Jean-François, Broet Philippe, Theodorou Ioannis
Abstract excerpt
Previous studies of the HIV-1 disease have shown that HLA and Chemokine receptor genetic variants influence disease progression and early viral load. We performed a Genome Wide Association study in a cohort of 605 HIV-1-infected seroconverters for detection of novel genetic factors that influence plasma HIV-RNA and cellular HIV-DNA levels. Most of the SNPs strongly associated with HIV-RNA levels were localised in...
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