Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of KIR2DS1 does not significantly contribute to NK cell cytotoxicity in HLA-C1/C2 heterozygous haplotype B donors.

International immunology - 1 Nov 2017

Baltner Karla, Kübler Ayline, Pal Marina, Balvociute Monika, Mezger Markus, Handgretinger Rupert, André Maya C

Abstract excerpt

NK cells are functionally controlled by the killer immunoglobulin-like receptor (KIR) family that comprises inhibitory (iKIR) and activating (aKIR) members. Genetic association studies suggest that donors expressing aKIRs next to iKIRs will be superior donors in the setting of hematopoietic stem cell transplantation of patients with leukemia. However, contrary evidence states that aKIR expression may be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coculture Techniques
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cell Transplantation

Share to HLA-C Antigens

Share to Killer Cells, Natural

Share to Leukemia

Share to Receptors, KIR

Share to Tissue Donors

Source

Identifiers

PMID: 29099970
DOI: 10.1093/intimm/dxx052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of KIR2DS1 does not significantly contribute to NK cell cytotoxicity in HLA-C1/C2 heterozygous haplotype B donors.PMID 29099970Read ↗

Expression of the HLA-C2-specific activating killer-cell Ig-like receptor KIR2DS1 on NK and T cells.Semantic proximity Read ↗

KIR2DS1-mediated activation overrides NKG2A-mediated inhibition in HLA-C C2-negative individuals.Semantic proximity Read ↗

Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands.Semantic proximity Read ↗

Large spectrum of HLA-C recognition by killer Ig-like receptor (KIR)2DL2 and KIR2DL3 and restricted C1 SPECIFICITY of KIR2DS2: dominant impact of KIR2DL2/KIR2DS2 on KIR2D NK cell repertoire formation.Semantic proximity Read ↗

Autologous and allogeneic HLA KIR ligand environments and activating KIR control KIR NK-cell functions.Semantic proximity Read ↗

Relevance of C1 and C2 Epitopes for Hemopoietic Stem Cell Transplantation: Role for Sequential Acquisition of HLA-C-Specific Inhibitory Killer Ig-Like ReceptorSemantic proximity Read ↗

Independent contributions of HLA epitopes and killer inhibitory receptor expression to the functional alloreactive specificity of natural killer cells.Semantic proximity Read ↗

NK-KIR ligand identification: a quick Q-PCR approach for HLA-C epitope typing.Semantic proximity Read ↗

Quantity of HLA-C surface expression and licensing of KIR2DL+ natural killer cells.Semantic proximity Read ↗

Estimation of the size of the alloreactive NK cell repertoire: studies in individuals homozygous for the group A KIR haplotype.Semantic proximity Read ↗

Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors.Semantic proximity Read ↗

Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.