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Article

Autologous and allogeneic HLA KIR ligand environments and activating KIR control KIR NK-cell functions.

European journal of immunology - 1 Dec 2008

Morvan Maelig, David Gaëlle, Sébille Véronique, Perrin Aurore, Gagne Katia, Willem Catherine, Kerdudou Nolwenn, Denis Laure, Clémenceau Béatrice, Folléa Gilles, Bignon Jean-Denis, Retière Christelle

Abstract excerpt

NK-cell function is regulated by a balance between inhibitory and activating killer cell immunoglobulin-like receptors (KIR) that specifically recognize HLA class I molecules. Using KIR-specific mAb to discriminate between KIR2DS1 and KIR2DL1 receptors, we show that KIR2DS1(+) NK cells are C2-alloreactive only from C2(-) individuals. Moreover, using an in vitro model of NK-cell expansion, we show here that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Herpesvirus 4, Human

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Share to Receptors, KIR

Source

Identifiers

PMID: 19016529
DOI: 10.1002/eji.200838407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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