Article
Quantity of HLA-C surface expression and licensing of KIR2DL+ natural killer cells.
Immunogenetics - 1 Oct 2012
Charoudeh Hojjatollah Nozad, Schmied Laurent, Gonzalez Asensio, Terszowski Grzegorz, Czaja Karol, Schmitter Karin, Infanti Laura, Buser Andreas, Stern Martin
Abstract excerpt
Natural killer (NK) cells require interaction of inhibitory surface receptors with human leukocyte antigen (HLA) ligands during development to acquire functional competence in a process termed "licensing." The quantity of HLA required for this process is unknown. Two polymorphisms affecting HLA-C surface expression (rs9264942 and rs67384697) have recently been identified, and shown to influence progression of HIV...
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