Article
Expression of the HLA-C2-specific activating killer-cell Ig-like receptor KIR2DS1 on NK and T cells.
Clinical immunology (Orlando, Fla.) - 1 Apr 2010
Cognet Céline, Farnarier Catherine, Gauthier Laurent, Frassati Coralie, André Pascale, Magérus-Chatinet Aude, Anfossi Nicolas, Rieux-Laucat Frederic, Vivier Eric, Schleinitz Nicolas
Abstract excerpt
Killer Ig-like receptors (KIRs) are MHC class I-specific receptors expressed by Natural Killer (NK) and T cell subsets. KIRs either inhibit (KIR-L) or activate (KIR-S) lymphocyte functions. Inhibitory KIR2DL1 and activating KIR2DS1 share ligand specificity for the HLA-C2 group, consistent with their almost identical extracytoplasmic domain. This homology hampered the distinction between KIR2DL1 and KIR2DS1. We...
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