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Article

Functional characterization of CYP2C19 variants in nebivolol 4-hydroxlation in vitro.

Drug testing and analysis - 1 May 2018

Zhou Xiao-Yang, Hu Xiao-Xia, Li Meng-Fang, Wang Hao, Zhang Li-Qun, Hu Guo-Xin, Cai Jian-Ping

Abstract excerpt

Cytochrome P450 2C19 (CYP2C19) allelic variants are thought to play an important part in inter-individual variability in drug metabolism. We evaluated the in vitro hydroxylation of nebivolol by 31 CYP2C19 alleles identified in a Chinese Han population recently. Wild-type CYP2C19*1B and 30 isoforms were highly expressed in insect cells, and the enzymatic activities of CYP2C19 variants towards nebivolol...

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PMID: 29098786
DOI: 10.1002/dta.2334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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