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Article

Important amino acid residues that confer CYP2C19 selective activity to CYP2C9.

Journal of biochemistry - 1 Sept 2008

Wada Yasunobu, Mitsuda Maori, Ishihara Yasuhiro, Watanabe Masatomo, Iwasaki Masahiko, Asahi Satoru

Abstract excerpt

Although CYP2C9 and CYP2C19 display 91% sequence identity at the amino acid level, the two enzymes have distinct substrate specificities for compounds such as diclofenac, progesterone and (S)-mephenytoin. Amino acid substitutions in CYP2C9 were made based on an alignment of CYP2C9, CYP2C19 and monkey CYP2C43 sequences. Mutants of CYP2C9 were expressed in Escherichia coli. Sixteen amino acids, which are common to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18511451
DOI: 10.1093/jb/mvn070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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