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In vitro functional analysis of 24 novel CYP2C19 variants recently found in the Chinese Han population.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Jan 2015

Dai Da-Peng, Hu Li-Ming, Geng Pei-Wu, Wang Shuang-Hu, Cai Jie, Hu Guo-Xin, Cai Jian-Ping

Abstract excerpt

1. CYP2C19 is a highly polymorphic enzyme responsible for the metabolism of a wide range of clinical drugs. Alterations to the CYP2C19 gene contribute to the variability of CYP2C19 enzyme activity, which causes pharmacokinetics and drug efficacies to vary and adverse drug reactions to occur in different persons. Recently, we identified 24 novel CYP2C19 allelic variants in the Chinese Han population. The purpose...

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Identifiers

PMID: 26153442
DOI: 10.3109/00498254.2015.1028512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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