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Article

Enzymatic activity of 38 CYP2C9 genotypes on ibuprofen.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Aug 2023

Yuan Ling-Jing, Li Xiang-Yu, Ye Feng, Li Xin-Yue, Li Qing-Qing, Zhong Yun-Shan, Wang Shi-Yu, Wang Ya-Hui, Hu Guo-Xin, Cai Jian-Ping, Li Jun-Wei

Abstract excerpt

BACKGROUND AND OBJECTIVE: Ibuprofen, a common non-steroidal anti-inflammatory drug, is used clinically for pain relief and antipyretic treatment worldwide. However, regular or long-term use of ibuprofen may lead to a series of adverse reactions, including gastrointestinal bleeding, hypertension and kidney injury. Previous studies have shown that CYP2C9 gene polymorphism plays an important role in the elimination...

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PMID: 37406757
DOI: 10.1016/j.fct.2023.113926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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