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Article

Evaluation of 24 CYP2D6 Variants on the Metabolism of Nebivolol In Vitro.

Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2016

Hu Xiaoxia, Lan Tian, Dai Dapeng, Xu Ren-Ai, Yuan Lingjing, Zhou Quan, Li Yunxuan, Cai Jianping, Hu Guoxin

Abstract excerpt

CYP2D6 is an important cytochrome P450 (P450) enzyme that metabolizes approximately 25% of therapeutic drugs. Its genetic polymorphisms may significantly influence the pharmacokinetics and pharmacodynamics of clinically used drugs. Studying the effects of CYP2D6 on drug metabolism can help reduce adverse drug reactions and therapeutic failure to some extent. This study aimed to investigate the role of CYP2D6 in...

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PMID: 27538917
DOI: 10.1124/dmd.116.071811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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