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Article

Influence of CYP2D65 and 10 polymorphism on the pharmacokinetics of nebivolol in healthy Chinese subjects.

Journal of clinical pharmacy and therapeutics - 1 Aug 2020

Guo Lifang, Wang Shumin, Wan Zirui, Ni Siyang, Xu Benshan, Zhao Xiuli, Liu Lihong

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: Nebivolol, a selective β1 adrenoreceptor antagonist, is predominantly metabolized by cytochrome P450 (CYP)2D6 and shows a wide interindividual variability in pharmacokinetics. The present study was conducted to evaluate the effects of the major CYP2D6 polymorphisms on nebivolol disposition in healthy Chinese volunteers. METHODS: Twenty-eight volunteers were enrolled and classified as...

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Identifiers

PMID: 32379356
DOI: 10.1111/jcpt.13155

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